Effect of Celery Extract on Fructose Induced Insulin Resistance Rattus norvegicus

Diabetes mellitus (DM) is one of the global health problems and in top 4th ranks as main cause death developing countries (IDF, 2015). The pathogenesis type II DM involves abnormalities insulin secretion activity that leads to resistance. This research aims study efficacy celery (Apiumgraveolens) a prevention In this study, samples were 45 Wistar rats (Rattus norvegicus), male sex, aged 4-6 weeks, weight 150-175 grams,and had normal fasting blood glucose levels by tested before treatment. experimental animals divided into 5 groups, K1 was negative control group (insulin resistance given 20% fructose 1,86 g/kg BW PO qDay);K2 positive (those qDayand standard therapy metformin 500 mg/kg qDay); K3 treatment qDay extract 200 qDay; K4 400 K5 600 qDay. been every day for 60 days.Fasting measured using Glucometer. Fasting ELISA, HOMA-IR calculated standardized formula, GLUT4 protein expression immunohistochemistry. It end intervention, there significant decreased (FBG) compared with (p <0.05), characterized higher value group, especially <0.05). There an increase GLUT-4 on can be concluded has antihyperglycemia effect furthermore it prevent condition.