Effect of Celery Extract on Fructose Induced Insulin Resistance Rattus norvegicus

نویسندگان

چکیده

Diabetes mellitus (DM) is one of the global health problems and in top 4th ranks as main cause death developing countries (IDF, 2015). The pathogenesis type II DM involves abnormalities insulin secretion activity that leads to resistance. This research aims study efficacy celery (Apiumgraveolens) a prevention In this study, samples were 45 Wistar rats (Rattus norvegicus), male sex, aged 4-6 weeks, weight 150-175 grams,and had normal fasting blood glucose levels by tested before treatment. experimental animals divided into 5 groups, K1 was negative control group (insulin resistance given 20% fructose 1,86 g/kg BW PO qDay);K2 positive (those qDayand standard therapy metformin 500 mg/kg qDay); K3 treatment qDay extract 200 qDay; K4 400 K5 600 qDay. been every day for 60 days.Fasting measured using Glucometer. Fasting ELISA, HOMA-IR calculated standardized formula, GLUT4 protein expression immunohistochemistry. It end intervention, there significant decreased (FBG) compared with (p <0.05), characterized higher value group, especially <0.05). There an increase GLUT-4 on can be concluded has antihyperglycemia effect furthermore it prevent condition.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Vanadyl Sulfate on Fructose-Induced Insulin Resistance Rat

Insulin resistance syndrome, also referred to as the metabolic syndrome or syndrome X, refers to a constellation of common metabolic and cardiovascular disorders (e.g. obesity, type 2 diabetes mellitus, hypertension, and dyslipidemia), which are all cardiovascular risk factors. Insulin resistance can be induced by fructose-rich diet in rats. We investigated the effect of vanadyl sulfate (0.2 mg...

متن کامل

Antidiabetic Effect of Hydroalcholic Urtica dioica Leaf Extract in Male Rats with Fructose-Induced Insulin Resistance

Background: Urtica dioica has been used as antihypertensive, antihyperlipidemic and antidiabetic herbal medicine. The purpose of this study was to study the effect of hydroalcoholic extract of Urtica dioica on fructose-induced insulin resistance rats. Methods: Forty male Wistar rats were randomly divided into five groups including control, fructose, extract 50, extract 100 and extract 2...

متن کامل

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

effect of vanadyl sulfate on fructose-induced insulin resistance rat

insulin resistance syndrome, also referred to as the metabolic syndrome or syndrome x, refers to a constellation of common metabolic and cardiovascular disorders (e.g. obesity, type 2 diabetes mellitus, hypertension, and dyslipidemia), which are all cardiovascular risk factors. insulin resistance can be induced by fructose-rich diet in rats. we investigated the effect of vanadyl sulfate (0.2 mg...

متن کامل

Effect of Vanadyl Sulfate on Fructose-Induced Insulin Resistance Rat

Insulin resistance syndrome, also referred to as the metabolic syndrome or syndrome X, refers to a constellation of common metabolic and cardiovascular disorders (e.g. obesity, type 2 diabetes mellitus, hypertension, and dyslipidemia), which are all cardiovascular risk factors. Insulin resistance can be induced by fructose-rich diet in rats. We investigated the effect of vanadyl sulfate (0.2 mg...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Folia Medica Indonesiana

سال: 2021

ISSN: ['2355-8393', '2599-056X']

DOI: https://doi.org/10.20473/fmi.v56i4.24602